Microbial Fermentation

AbbVie Contract Manufacturing offers world-class fermentation services based on more than 60 years of leadership in fermentation.



All Things Great and Small

A partner like no other.

The North Chicago site is a unique asset in North America with more than 3 million liters of aerobic fermentation capacity and a variety of downstream capabilities to support numerous types of organisms.  These capabilities combined with a pilot plant that mimics all of the commercial scale capabilities enables AbbVie to successfully deliver all of your project needs from process development to commercial manufacturing. 

Types of Products

  • Small molecule API
  • Large molecule API administered orally
  • Bulk food ingredients
  • Semi-synthetic API’s

Types of Organisms

  • GMO & non-GMO
  • Streptomyces
  • e. coli
  • Fungi
  • Bacillus
  • Yeast

Pilot Plant

  • Preparation of R&D, master and working cell banks
  • Inoculum process development
  • Fermentation process optimization at 55 and 500 L scale
  • Downstream process optimization and characterization

Microbial Fermentation Manufacturing

  • 3,000 m3 fermentation capacity
  • Fermenter working volumes from 10 to 100 m3
  • Downstream capabilities including microfiltration, centrifugation, extraction, ultrafiltration, chromatography, crystallization and fluid-bed drying
  • Bulk packaging of liquids into totes and tanker trucks and dried solids into drums


  • Spectrophotometry
  • Wet chemistry including LOD, pH, heavy metals
  • Stability testing
  • On-site microbial lab including bioburden

An AbbVie CMO representative is eager to talk to you.

AbbVie CMO is a seasoned partner for all your contract manufacturing needs. Let’s start a conversation today. The future is a click away.