Microbial Fermentation

AbbVie Contract Manufacturing offers world-class fermentation services based on more than 60 years of leadership in fermentation.  The North Chicago site is a unique asset in North America with more than 3 million liters of aerobic fermentation capacity and a variety of downstream capabilities to support numerous types of organisms.



All Things Great and Small

Nature — A partner like no other.

These capabilities combined with a pilot plant that mimics all of the commercial scale capabilities enables AbbVie to successfully deliver all of your project needs from process development to commercial manufacturing.  For efficiency and sustainability, AbbVie CMO’s fermentation operation draws on local crop and water sources. This unique, local access to raw materials sets AbbVie CMO apart, allowing us to scale-up microbial fermentation as demand grows.

Types of Products

  • Small molecule API
  • Large molecule API administered orally
  • Bulk food ingredients
  • Semi-synthetic API’s

Types of Organisms

  • GMO & non-GMO
  • Streptomyces
  • e. coli
  • Fungi
  • Bacillus
  • Yeast

Pilot Plant

  • Preparation of R&D, master and working cell banks
  • Inoculum process development
  • Fermentation process optimization at 55 and 500 L scale
  • Downstream process optimization and characterization

Microbial Fermentation Manufacturing

  • 3,000 m3 fermentation capacity
  • Fermenter working volumes from 10 to 100 m3
  • Downstream capabilities including microfiltration, centrifugation, extraction, ultrafiltration, chromatography, crystallization and fluid-bed drying
  • Bulk packaging of liquids into totes and tanker trucks and dried solids into drums


  • Spectrophotometry
  • Wet chemistry including LOD, pH, heavy metals
  • Stability testing
  • On-site microbial lab including bioburden

An AbbVie CMO representative is eager to talk to you.

AbbVie CMO is a seasoned partner for all your contract manufacturing needs. Let’s start a conversation today. The future is a click away.