Commercial Scale
- 100–700 kg/batch depending on process complexity
- Total site annual capacity of ~20–30 metric tons
- Several 10,000 L – 12,500 L tanks (stainless steel and glass lined)
- Large scale stainless steel and Hastelloy filter dryers
- Reaction monitoring via OSI-PI software web-based access
- Multipurpose facility with CAPEX options
Expertise
- Organometallic (Grignard)
- Gaseous HCl
- Acetylene Chemistry
- Friedel-Crafts Chemistry
- Cyanation
- Hydride
- DIBAL reductions
- Chlorinated Solvents
- Chromatography
Process Analytical Technologies (PATs)
- Mass spectrum analysis for distillations and drying profiling
- FTIR for reaction completion
- FBRM/PVM for crystallization
- Raman for drying endpoint
- Online particle size measurement
- Conductivity for phase separations
- Refractive index for cake wash solvent displacement
Analytical and Microbiological Testing
- HPLC (reverse/normal phase and ion exchange, with UV/Vis, RI, fluorescence, ECD and ELS detection)
- GC (direct injection and headspace analysis with FID and TCD detection)
- ICP-OES, ICP-MS, GC-MS and LC-MS
- Spectroscopy (FT-IR, UV/Vis and AA)
- Powder X-Ray Diffraction, DSC Optical Electron Microscopy Surface Area and Particle Size Analysis
- Dissolution USP Apparatus 1, 2 and 3
- Cleaning Methods (LC and TOC)
- Microbiology Testing
- ICH Stability Storage and Testing