AbbVie Contract Manufacturing offers world-class fermentation capabilities based on more then 60 years’ leadership in fermentation. Your project will benefit from AbbVie’s scientific expertise as a leading development and manufacturer of fermentation processes at our 180-acre facility in Chicago, Illinois. We bring the same degree of expertise and passion to your project as we do with our own, supporting you from cell bank development through to large-scale manufacturing.

Types of Products


  • GMO & non-GMO manufactured under GLSP (good large scale practice)
  • Pharmaceutical small molecule API’s to be administered orally or as an injectable
  • Pharmaceutical large molecule API’s to be administered orally
  • Bulk food ingredients
  • Agrochemical active ingredients
  • Semi-synthetic products
  • Biopesticides
  • Enzymes

Types of Organisms


  • Experience with
    • Actinomycetes
    • E. coli 
    • Streptomyces
    • Fungi 
    • Bacillus 
    • Yeast


Yeast and microbial organisms consume large amounts of water and nutrients, making pharmaceutical fermentation processes resource-heavy endeavors. For time and cost-efficiency, AbbVie Contract Manufacturing has established a facility to sustainably draw on local crops and water sources. This unique access to raw materials used for industrial fermentation directly benefits pharmaceutical and toll manufacturing partners looking for high quality, cost-effective contract fermentation services.

Once established, companies can scale-up fermentation orders as commercial demand grows. AbbVie is committed to maintaining a secure supply chain to reliably meet long-term toll manufacturing and pharmaceutical fermentation demand.

Development Manufacturing (NON-GMP) 


  • Strain improvement via classical and recombinant methods
  • Preparation of R&D, master and working cell banks
  • Inoculum process development
  • Fermentation and downstream process development and characterization including:
    • 55 L - 500 L fermenters in pilot plant
    • Track key parameters including pH, DO, temperature, agitation and off-gas
    • Recovery operations that are representative of commercial scale 
    • Method development and transfer for analytical, microbial and cleaning methods

Clinical and Commercial Manufacturing


  • Over 3,000 m3 fermentation capacity 
  • Fermenter working volumes from 10,000 L – 100,000 L 
  • Batch and continuous sterilization of media 
  • Dedicated facility for cell bank preparation and storage with redundant equipment and controls 
  • Broad range of downstream capabilities including: 
    • Microfiltration - Chromatography 
    • Centrifugation - Crystallization 
    • Liquid / Liquid extraction - Fluid bed drying 
    • Ultrafiltration - Filter drying 
    • Evaporation
  • Packaging liquids into presterilized totes or tanker trucks and dried solids into drum